POS1408 REPRODUCIBILITY OF A NEW AUTOMATIC SYSTEM (CAPILLARY.IO) IN THE ANALYSIS OF NAILFOLD CAPILLAROSCOPY IMAGES

Background: Nailfold Capillaroscopy is a simple, inexpensive and non-invasive technique that allows microvascular damage to be observed, gaining recent importance in the diagnosis, monitoring prognosis of many diseases with microangiopathy. However, variability results interpretation has led development new computerized systems allow automatic analysis capillaroscopic images. Objectives: compare degree agreement between system Capillary.io gold standard obtained from 9 expert capillaroscopists know interobserver reliability To demonstrate validity detect normal enlarged capillaries, hemorrhages, megacapillaries, ramifications tortuosities. Methods: cross-sectional study was performed which 300 random anonymous nailfold images (1165 capillaries) were analyzed by experienced observers. The calculated 5 users. Likewise, an assessment their (interobserver greater than 5, 6, 7, 8 successively). program for each variable also using sensitivity specificity, positive negative predictive values, likelihood ratios, as well weighted kappa statistic (95% CI, p <0.05). programs used statistical calculations SPSS 22.0 EPIDAT 3.0. Results: 76.5% or more observers, progressively decreasing 15.4% higher levels agreement, reaching 97.7% Statistically significant automated detection all morphological alterations presented (S) 79.82% specificity (E) 82% recognition capillaries. automatized able recognize capillaries 86.97% 81.38%. Megacapillaries detected 89.41% 78.75% specificity. Similarly, tortuosities (S 66.94%; E 67.71%), 54.34%; 58.61%) hemorrhages 71.36; 73.97%). Conclusion: demonstrated high standard, stronger consensus among It great very relevant microangiopathies. References: [1]Roldán LMC, Franco CJV, Navas MAM. systemic sclerosis: A narrative literature review. Rev Colomb Reumatol; 2016; 23: 250-8. [2]Ingegnoli F, Gualtierotti R, Lubatti C, Bertolazzi Gutierrez M, Boracchi P, et al. capillary patterns healthy subjects: real issue capillaroscopy. Microvasc Res. 2013;90:90-5. [3]Cutolo Pizzorni Secchi ME, Sulli A. Capillaroscopy. Best Pract Res Clin Rheumatol. 2008; 22:1093-108. [4]Tavakol Fatemi A, Karbalaie Emrani Z, Erlandsson BE. Rheumatic Diseases: Which Parameters Should Be Evaluated? BioMed Int. 2015; 2015: 974530. [5]Smith V, Herrick AL, Ingegnoli Damjanov N, De Angelis Denton CP, Standardisation capillaroscopy patients Raynaud’s phenomenon sclerosis. Autoimmunity Reviews. 2020; 19: 102458. Disclosure Interests: Borja Gracia Tello Shareholder of: Co-founder shareholder Capillary.io., Eduardo Ramos Carmen Pilar Simeón-Aznar: None declared, Vicent Fonollosa Pla: Alfredo Guillén-Del-Castillo: Albert Selva-O’Callaghan: Luis Sáez-Comet: Elena Martínez Robles: Juan José Rios: Gerard Espinosa: Jose Antonio Todolí Parra: Callejas-Rubio: Norberto Ortego: Begoña Marí-Alfonso: Mayka Freire: Patricia Fanlo: declared